A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

@article{Ridge1998ACD,
  title={A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell},
  author={John Paul Ridge and Francesca Di Rosa and Polly Matzinger},
  journal={Nature},
  year={1998},
  volume={393},
  pages={474-478}
}
To generate an immune response, antigen-specific T-helper and T-killer cells must find each other and, because they cannot detect each other's presence, they are brought together by an antigen-loaded dendritic cell that displays antigens to both. This three-cell interaction, however, seems nearly impossible because all three cell types are rare and migratory. Here we provide a potential solution to this conundrum. We found that the three cells need not meet simultaneously but that the helper… 
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TLDR
Recent advances in understanding of DC licensing for cross-priming are discussed and implications for the temporal and spatial regulation underlying this process are discussed.
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TLDR
It is found that CD4 T cells establish a negative feedback loop by capturing their cognate major histocompatibility class (MHC)/peptide complexes from Ag-presenting cells and presenting them to Ag-experienced CD4T cells, thereby inhibiting their recruitment into the response while allowing recruitment of naive T cells.
Not all effector CD8+ T cells are alike.
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