A conditionally replicative adenovirus with enhanced infectivity shows improved oncolytic potency.

@article{Suzuki2001ACR,
  title={A conditionally replicative adenovirus with enhanced infectivity shows improved oncolytic potency.},
  author={Kaori Suzuki and Juan Fueyo and Victor N. Krasnykh and Paul N. Reynolds and David T. Curiel and Ramon Alemany},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2001},
  volume={7 1},
  pages={120-6}
}
The absence or the presence of low levels of the Coxsackievirus and adenovirus receptor (CAR) on several tumor types might limit the efficacy of recently proposed tumor-specific or conditionally replicative adenoviruses (CRAds). To address this issue, we used a genetic modification of the fiber knob in the context of an E1A-defective CRAd to allow CAR-independent target cell infection as a means to enhance oncolytic potency. Such infectivity-enhanced CRAd showed higher replication, more… CONTINUE READING