A conceptually new type of bio-hybrid scaffold for bone regeneration.

Abstract

Magnetic bio-hybrid porous scaffolds have been synthesized, nucleating nano-apatite in situ on self-assembling collagen, in the presence of magnetite nano-particles. The magnetic phase acted as a sort of cross-linking agent for the collagen, inducing a chemico-physical-mechanical stabilization of the material and allowing us to control the porosity network of the scaffold. Gradients of bio-mineralization and magnetization were also developed for osteochondral application. The good potentiality of the material as a biomedical device, able to offer assistance to bone regeneration through scaffold reloading with specific factors guided by an external magnetic field, has been preliminarily investigated. Up to now the proof of this concept has been realized through in vitro assessments.

DOI: 10.1088/0957-4484/22/1/015104
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Cite this paper

@article{Tampieri2011ACN, title={A conceptually new type of bio-hybrid scaffold for bone regeneration.}, author={A. Tampieri and E. Landi and Federica Valentini and Maura Sandri and Teresa D'Alessandro and Vlad Dediu and Maurilio Marcacci}, journal={Nanotechnology}, year={2011}, volume={22 1}, pages={015104} }