A concentrated and stable aerosol formulation of cationic lipid:DNA complexes giving high-level gene expression in mouse lung.

@article{Eastman1997ACA,
  title={A concentrated and stable aerosol formulation of cationic lipid:DNA complexes giving high-level gene expression in mouse lung.},
  author={Simon J Eastman and Mike J. Lukason and Jennifer D Tousignant and Heather Murray and Michael Douglas Lane and Judith A St George and Geoffrey Y. Akita and Maribeth Cherry and Seng H. Cheng and Ronald K. Scheule},
  journal={Human gene therapy},
  year={1997},
  volume={8 6},
  pages={765-73}
}
Advances in gene therapy vectors and techniques hold promise for treatment of many inherited and acquired diseases. For lung indications, especially those involving the epithelium, delivery of the gene therapy vehicle ideally will involve the use of an aerosol. Aerosol delivery of transgenes using cationic lipids is currently limited by the ability to generate highly concentrated formulations of lipid:DNA complexes that are stable and retain their activity following aerosolization. We have… CONTINUE READING

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