A computerized image analysis system for quantitative analysis of cells in histological brain sections.

@article{Benali2003ACI,
  title={A computerized image analysis system for quantitative analysis of cells in histological brain sections.},
  author={Alia Benali and Iris Leefken and Ulf T. Eysel and Elke Weiler},
  journal={Journal of neuroscience methods},
  year={2003},
  volume={125 1-2},
  pages={33-43}
}
We propose a reliable method for automatic counting of cells in brain sections labeled with different antibodies (against NeuN, parvalbumin, GABA and c-Fos) and in Nissl-staining. Images of stained sections are converted to binary images by thresholding. Clusters of 'ON pixels' (value of 1) corresponding to cell bodies are selected based on size. The parameters of the algorithm (intensity range and cluster-size) are adjusted for different methods of staining according to expert knowledge. The… CONTINUE READING

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