A computer algorithm describing the process of vessel formation and maturation, and its use for predicting the effects of anti-angiogenic and anti-maturation therapy on vascular tumor growth

@article{Arakelyan2002ACA,
  title={A computer algorithm describing the process of vessel formation and maturation, and its use for predicting the effects of anti-angiogenic and anti-maturation therapy on vascular tumor growth},
  author={Levon Arakelyan and Vladimir Vainstein and Zvia Agur},
  journal={Angiogenesis},
  year={2002},
  volume={5},
  pages={203-214}
}
We put forward an algorithm describing the three principal interconnected sub-processes that influence tumor and vasculature dynamics: (i) tumor cell proliferation (ii) angiogenesis, that is, the formation and regression of immature vessels (IV), and (iii) maturation, i.e., the formation and destabilization of mature vessels (MV). This algorithm takes account of the crucial quantitative interactions of these sub-processes, occurring across the molecular, cellular and organ levels. Implementing… CONTINUE READING

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Differential expression of Angiopoietin-1 and Angiopoietin-2 in colon carcinoma

  • SA Ahmad
  • Cancer
  • 2001
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