A computational strategy to adjust for copy number in tumor Hi-C data


MOTIVATION The Hi-C technology was designed to decode the three-dimensional conformation of the genome. Despite progress towards more and more accurate contact maps, several systematic biases have been demonstrated to affect the resulting data matrix. Here we report a new source of bias that can arise in tumor Hi-C data, which is related to the copy number… (More)
DOI: 10.1093/bioinformatics/btw540