A computational model predicts Xenopus meiotic spindle organization

@inproceedings{Loughlin2010ACM,
  title={A computational model predicts Xenopus meiotic spindle organization},
  author={R. MacLean Loughlin and Rebecca Heald and François J N{\'e}d{\'e}lec},
  booktitle={The Journal of cell biology},
  year={2010}
}
The metaphase spindle is a dynamic bipolar structure crucial for proper chromosome segregation, but how microtubules (MTs) are organized within the bipolar architecture remains controversial. To explore MT organization along the pole-to-pole axis, we simulated meiotic spindle assembly in two dimensions using dynamic MTs, a MT cross-linking force, and a kinesin-5-like motor. The bipolar structures that form consist of antiparallel fluxing MTs, but spindle pole formation requires the addition of… CONTINUE READING
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