A computational model of the hypothalamic - pituitary - gonadal axis in female fathead minnows (Pimephales promelas) exposed to 17α-ethynylestradiol and 17β-trenbolone

@inproceedings{Li2010ACM,
  title={A computational model of the hypothalamic - pituitary - gonadal axis in female fathead minnows (Pimephales promelas) exposed to 17α-ethynylestradiol and 17β-trenbolone},
  author={Zhenhong Li and Kevin J. Kroll and Kathleen M. Jensen and Daniel L. Villeneuve and Gerald T. Ankley and Jayne V. Brian and Mar{\'i}a S. Sep{\'u}lveda and Edward F. Orlando and James M. Lazorchak and Mitchell Kostich and Brandon Armstrong and Nancy D. Denslow and Karen H. Watanabe},
  booktitle={BMC Systems Biology},
  year={2010}
}
Endocrine disrupting chemicals (e.g., estrogens, androgens and their mimics) are known to affect reproduction in fish. 17α-ethynylestradiol is a synthetic estrogen used in birth control pills. 17β-trenbolone is a relatively stable metabolite of trenbolone acetate, a synthetic androgen used as a growth promoter in livestock. Both 17α-ethynylestradiol and 17β-trenbolone have been found in the aquatic environment and affect fish reproduction. In this study, we developed a physiologically-based… CONTINUE READING
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What is normal? Biological variability in reproductive parameters of unexposed fathead minnows (Pimephales promelas)

  • KH Watanabe, KM Jensen, EF Orlando, GT Ankley
  • Comp Biochem Physiol C Toxicol Pharmacol
  • 2007
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