A computational model of mitochondrial deoxynucleotide metabolism and DNA replication.

@article{Bradshaw2005ACM,
  title={A computational model of mitochondrial deoxynucleotide metabolism and DNA replication.},
  author={P. Bradshaw and D. Samuels},
  journal={American journal of physiology. Cell physiology},
  year={2005},
  volume={288 5},
  pages={
          C989-1002
        }
}
We present a computational model of mitochondrial deoxynucleotide metabolism and mitochondrial DNA (mtDNA) synthesis. The model includes the transport of deoxynucleosides and deoxynucleotides into the mitochondrial matrix space, as well as their phosphorylation and polymerization into mtDNA. Different simulated cell types (cancer, rapidly dividing, slowly dividing, and postmitotic cells) are represented in this model by different cytoplasmic deoxynucleotide concentrations. We calculated the… Expand
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