A computational model of mitochondrial AZT metabolism.

@article{Bradshaw2005ACM,
  title={A computational model of mitochondrial AZT metabolism.},
  author={Patrick C. Bradshaw and Jiaxin Li and David C. Samuels},
  journal={The Biochemical journal},
  year={2005},
  volume={392 Pt 2},
  pages={
          363-73
        }
}
The mechanisms of the mitochondrial toxicity of AZT (azidothymidine; zidovudine) are not clear. The two main contenders are the incorporation of phosphorylated AZT into the mtDNA (mitochondrial DNA) and the competitive inhibition of natural deoxynucleotide metabolism. We have built a computational model of AZT metabolism in mitochondria in order to better understand these toxicity mechanisms. The model includes the transport of non-phosphorylated and phosphorylated forms of AZT into… 

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