A computational model of human granulopoiesis to simulate the hematotoxic effects of multicycle polychemotherapy.

@article{Engel2004ACM,
  title={A computational model of human granulopoiesis to simulate the hematotoxic effects of multicycle polychemotherapy.},
  author={Christoph Engel and Markus Scholz and Markus L{\"o}ffler},
  journal={Blood},
  year={2004},
  volume={104 8},
  pages={2323-31}
}
Moderate intensification of conventional multicycle chemotherapy has recently been shown to improve treatment results in malignant lymphomas and might prove to be beneficial also in other malignancies. However, the feasibility of such regimens is mainly limited by their granulopoietic toxicity. To identify and quantify the basic cell kinetic mechanisms of damage and stimulation caused by cytotoxic drugs and recombinant human granulocyte colony-stimulating factor (rhG-CSF), respectively, we… CONTINUE READING