A computational model of adipose tissue metabolism: evidence for intracellular compartmentation and differential activation of lipases.

@article{Kim2008ACM,
  title={A computational model of adipose tissue metabolism: evidence for intracellular compartmentation and differential activation of lipases.},
  author={Jaeyeon Kim and Gerald M. Saidel and Satish C. Kalhan},
  journal={Journal of theoretical biology},
  year={2008},
  volume={251 3},
  pages={
          523-40
        }
}
Regulation of lipolysis in adipose tissue is critical to whole body fuel homeostasis and to the development of insulin resistance. Due to the challenging nature of laboratory investigations of regulatory mechanisms in adipose tissue, mathematical models could provide a valuable adjunct to such experimental work. We have developed a computational model to analyze key components of adipose tissue metabolism in vivo in human in the fasting state. The various key components included triglyceride… CONTINUE READING
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