A computational model for telomere-dependent cell-replicative aging

Abstract

Telomere shortening provides a molecular basis for the Hayflick limit. Recent data suggest that telomere shortening also influence mitotic rate. We propose a stochastic growth model of this phenomena, assuming that cell division in each time interval is a random process which probability decreases linearly with telomere shortening. Computer simulations of… (More)
DOI: 10.1016/j.biosystems.2007.10.003

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