A computational framework for the topological analysis and targeted disruption of signal transduction networks.

@article{Dasika2006ACF,
  title={A computational framework for the topological analysis and targeted disruption of signal transduction networks.},
  author={Madhukar S. Dasika and Anthony P. Burgard and Costas D. Maranas},
  journal={Biophysical journal},
  year={2006},
  volume={91 1},
  pages={382-98}
}
In this article, optimization-based frameworks are introduced for elucidating the input-output structure of signaling networks and for pinpointing targeted disruptions leading to the silencing of undesirable outputs in therapeutic interventions. The frameworks are demonstrated on a large-scale reconstruction of a signaling network composed of nine signaling pathways implicated in prostate cancer. The Min-Input framework is used to exhaustively identify all input-output connections implied by… CONTINUE READING