A computational framework for the design of optimal protein synthesis.

@article{Racle2012ACF,
  title={A computational framework for the design of optimal protein synthesis.},
  author={Julien Racle and Jan Overney and Vassily Hatzimanikatis},
  journal={Biotechnology and bioengineering},
  year={2012},
  volume={109 8},
  pages={2127-33}
}
Despite the establishment of design principles to optimize codon choice for heterologous expression vector design, the relationship between codon sequence and final protein yield remains poorly understood. In this work, we present a computational framework for the identification of a set of mutant codon sequences for optimized heterologous protein production, which uses a codon-sequence mechanistic model of protein synthesis. Through a sensitivity analysis on the optimal steady state… CONTINUE READING
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