A computational framework for temporal sharpening of stimulus input in the olfactory 1 system 2 3 4

Abstract

A computational framework for temporal sharpening of stimulus input in the olfactory 1 system 2 3 4 Joseph D. Zak 5 6 Neuroscience Program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045 7 8 9 Abstract 10 11 The olfactory bulb glomerulus is a dense amalgamation of many unique and 12 interconnected cell types. The mechanisms by which these neurons transform incoming 13 information from the sensory periphery have been extensively studied but often with conflicting 14 findings. A recent study by Carey et al. (J Neurophysiol 113: 3112-3129, 2015) details the 15 computational framework for parallel modes of temporal refinement of stimulus input to the 16 olfactory system mediated by local neurons within individual glomeruli. 17 18 Main Text 19 A key feature of the olfactory system is its ability to extract stimulus information in a 20 temporally phasic manner that is constrained by the respiratory cycle. This arrangement allows 21 for independent sampling of the stimulus environment with each new sniff. Due to the sinusoidal 22 nature of olfactory input, it is important that the activity of bulbar output neurons is tightly 23 coupled with the respiration cycle to avoid cross-contamination between sampling events. 24 Indeed, experimental evidence suggests that the activity of olfactory receptor neurons (ORNs) 25 far outlasts the activity of downstream olfactory bulb output neurons (mitral cells; MCs; Carey 26 and Wachowiak, 2011). How the spike output of MCs is temporally refined with respect to 27 sensory input remains largely unresolved but it is postulated to result from both excitatory and 28 inhibitory signaling from local neurons that also comprise the glomerular neuropil (Hayar et al., 29 2004, Murphy et al., 2005, Najac et al., 2015). The mechanisms by which small groups of 30 Articles in PresS. J Neurophysiol (September 2, 2015). doi:10.1152/jn.00785.2015

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@inproceedings{Zak2015ACF, title={A computational framework for temporal sharpening of stimulus input in the olfactory 1 system 2 3 4}, author={Joseph D Zak}, year={2015} }