A computational approach to measuring coherence of gene expression in pathways.

@article{Yang2004ACA,
  title={A computational approach to measuring coherence of gene expression in pathways.},
  author={Howard Hua Yang and Ying Hu and Kenneth H. Buetow and Maxwell P. Lee},
  journal={Genomics},
  year={2004},
  volume={84 1},
  pages={211-7}
}
This study uses a computational approach to analyze coherence of expression of genes in pathways. Microarray data were analyzed with respect to coherent gene expression in a group of genes defined as a pathway in the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. Our hypothesis is that genes in the same pathway are more likely to be coordinately regulated than a randomly selected gene set. A correlation coefficient for each pair of genes in a pathway was estimated based on gene… CONTINUE READING

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