A computational approach to map nucleosome positions and alternative chromatin states with base pair resolution

@inproceedings{Zhou2016ACA,
  title={A computational approach to map nucleosome positions and alternative chromatin states with base pair resolution},
  author={Xu Zhou and Alexander W. Blocker and Edoardo M. Airoldi and Erin K O'Shea},
  booktitle={eLife},
  year={2016}
}
Understanding chromatin function requires knowing the precise location of nucleosomes. MNase-seq methods have been widely applied to characterize nucleosome organization in vivo, but generally lack the accuracy to determine the precise nucleosome positions. Here we develop a computational approach leveraging digestion variability to determine nucleosome… CONTINUE READING

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