A computational approach for designing D-proteins with non-canonical amino acid optimised binding affinity

@inproceedings{Garton2017ACA,
  title={A computational approach for designing D-proteins with non-canonical amino acid optimised binding affinity},
  author={Michael Garton and Maryam Sayadi and Philip M. Kim},
  booktitle={PloS one},
  year={2017}
}
Redesigning protein surface topology to improve target binding holds great promise in the search for highly selective therapeutics. While significant binding improvements can be achieved using natural amino acids, the introduction of non-canonical residues vastly increases sequence space and thus the chance to significantly out-compete native partners. The potency of protein inhibitors can be further enhanced by synthesising mirror image, D-amino versions. This renders them non-immunogenic and… CONTINUE READING
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