A comprehensive two-hybrid analysis to explore the yeast protein interactome.

@article{Ito2001ACT,
  title={A comprehensive two-hybrid analysis to explore the yeast protein interactome.},
  author={Takashi Ito and Tomoki Chiba and Rika Ozawa and Masaki Yoshida and Masahira Hattori and Yoshiyuki Sakaki},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 8},
  pages={4569-74}
}
Protein-protein interactions play crucial roles in the execution of various biological functions. Accordingly, their comprehensive description would contribute considerably to the functional interpretation of fully sequenced genomes, which are flooded with novel genes of unpredictable functions. We previously developed a system to examine two-hybrid interactions in all possible combinations between the approximately 6,000 proteins of the budding yeast Saccharomyces cerevisiae. Here we have… CONTINUE READING
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