A comprehensive transcriptional portrait of human cancer cell lines

Abstract

Tumor-derived cell lines have served as vital models to advance our understanding of oncogene function and therapeutic responses. Although substantial effort has been made to define the genomic constitution of cancer cell line panels, the transcriptome remains understudied. Here we describe RNA sequencing and single-nucleotide polymorphism (SNP) array… (More)
DOI: 10.1038/nbt.3080

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Cite this paper

@article{Klijn2015ACT, title={A comprehensive transcriptional portrait of human cancer cell lines}, author={Christiaan Klijn and Steffen Durinck and Eric W. Stawiski and Peter M. Haverty and Zhaoshi Jiang and Hanbin Liu and Jeremiah D. Degenhardt and Oleg Mayba and Florian Gnad and Jinfeng Liu and Gr{\'e}goire Pau and Jens Reeder and Yi Cao and Kiran Mukhyala and Suresh K. Selvaraj and Mamie Yu and Gregory J Zynda and Matthew J. Brauer and Thomas D. Wu and Robert Gentleman and Gerard Manning and Robert L. Yauch and Richard Bourgon and David Stokoe and Zora Modru{\vs}an and Richard M. Neve and Frederic J. de Sauvage and Jeffrey E. Settleman and Somasekar Seshagiri and Zemin Zhang}, journal={Nature Biotechnology}, year={2015}, volume={33}, pages={306-312} }