A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets

@inproceedings{Deng2012ACS,
  title={A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets},
  author={Niantao Deng and Liang Kee Goh and Hannah Zhu'Ai Wang and Kakoli Das and Jiong Tao and Iain Beehuat Tan and Shenli Zhang and Minghui Lee and Jeanie Wu and Kiat Hon Tony Lim and Zhengdeng Lei and Glenn Goh and Qing-Yan Lim and Angie Lay-Keng Tan and Dianne Yu Sin Poh and Sudep Riahi and Sandra M. Bell and Michael Ming Shi and Ronald Linnartz and Feng Zhu and Khay Guan Yeoh and Han Chong Toh and Wei Peng Yong and Hyun Cheol Cheong and Sun Young Rha and Alex Boussioutas and Heike I Grabsch and Steven G Rozen and Patrick O. B. Tan},
  booktitle={Gut},
  year={2012}
}
OBJECTIVE Gastric cancer is a major gastrointestinal malignancy for which targeted therapies are emerging as treatment options. This study sought to identify the most prevalent molecular targets in gastric cancer and to elucidate systematic patterns of exclusivity and co-occurrence among these targets, through comprehensive genomic analysis of a large panel of gastric cancers. DESIGN Using high-resolution single nucleotide polymorphism arrays, copy number alterations were profiled in a panel… CONTINUE READING
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