A comprehensive study of iRGD-modified liposomes with improved chemotherapeutic efficacy on B16 melanoma.

@article{Dai2015ACS,
  title={A comprehensive study of iRGD-modified liposomes with improved chemotherapeutic efficacy on B16 melanoma.},
  author={Wenbing Dai and Yuchen Fan and Hua Zhang and Xueqing Wang and Qiang Zhang and Xinglin Wang},
  journal={Drug delivery},
  year={2015},
  volume={22 1},
  pages={
          10-20
        }
}
iRGD is a tumor tissue penetrating peptide due to its targeted binding of integrin and neuropilin-1 receptors. Whether iRGD carries the liposomes in a similar way as it penetrates the cancer drugs or conjugated drugs into tumor tissues and cells has not been fully defined. Here, iRGD-modified and doxorubicin-loaded sterically stabilized liposomes (iRGD-SSL-DOX) and passive liposomes (SSL-DOX) were prepared. A series of experiments were performed to evaluate the tissue penetration, cell… CONTINUE READING
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