A comprehensive statistical analysis of predicting in vivo hazard using high-throughput in vitro screening.

@article{Thomas2012ACS,
  title={A comprehensive statistical analysis of predicting in vivo hazard using high-throughput in vitro screening.},
  author={Russell S. Thomas and Michael B. Black and Lili Li and Eric Healy and Tzu-Ming Chu and Wenjun Bao and Melvin E. Andersen and Russell D. Wolfinger},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2012},
  volume={128 2},
  pages={398-417}
}
Over the past 5 years, increased attention has been focused on using high-throughput in vitro screening for identifying chemical hazards and prioritizing chemicals for additional in vivo testing. The U.S. Environmental Protection Agency's ToxCast program has generated a significant amount of high-throughput screening data allowing a broad-based assessment of the utility of these assays for predicting in vivo responses. In this study, a comprehensive cross-validation model comparison was… CONTINUE READING
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