A comprehensive review of vitamin K and vitamin K antagonists.

  title={A comprehensive review of vitamin K and vitamin K antagonists.},
  author={Cees Vermeer and Leon J Schurgers},
  journal={Hematology/oncology clinics of North America},
  volume={14 2},
For more than 60 years, vitamin K-dependent proteins have been known to play an important role in regulating blood coagulation. During recent years it has become clear, however, that vitamin K is also involved in other physiologic processes, including bone metabolism and vascular biology. Because the vitamin K requirement of bone and vessel wall is higher than that of the liver (where the clotting factors are produced) recommended daily allowance (RDA) values for K vitamins must be redefined… CONTINUE READING

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