A comprehensive model of positional and stereo control in lipoxygenases.

  title={A comprehensive model of positional and stereo control in lipoxygenases.},
  author={Gianguido Coffa and Claus Schneider and Alan R. Brash},
  journal={Biochemical and biophysical research communications},
  volume={338 1},
The lipoxygenase gene family can synthesize an array of chiral hydroperoxy derivatives from polyunsaturated fatty acids. An individual enzyme, however, reacts molecular oxygen on a single position on the carbon chain and in a single stereo configuration. Regiospecificity is regulated by the orientation and depth of substrate entry into the active site. Stereospecificity is a different issue and only recently has experimental support emerged to explain the conceptual basis of stereo control. A… CONTINUE READING

From This Paper

Topics from this paper.
28 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 28 extracted citations

Similar Papers

Loading similar papers…