A comprehensive mathematical model of stem cell proliferation which reproduces most of the published experimental results.

@article{Lffler1980ACM,
  title={A comprehensive mathematical model of stem cell proliferation which reproduces most of the published experimental results.},
  author={Markus L{\"o}ffler and Hans E Wichmann},
  journal={Cell and tissue kinetics},
  year={1980},
  volume={13 5},
  pages={543-61}
}
On the basis of experimental knowledge about haemopoietic stem cells a catalogue of fundamental statements is formulated. From this a simple mathematical model of haemopoietic regulation mechanisms is developed. The functional net effects of regulatory processes which are still unknown or unmeasurable are estimated using evolution arguments. The model is developed in three steps. It allows description of the self-replication of stem cells after direct destruction as well as their reaction to… CONTINUE READING

From This Paper

Topics from this paper.
23 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

Similar Papers

Loading similar papers…