A comprehensive long-term retrospective analysis of silent corticotrophic adenomas vs hormone-negative adenomas.

@article{Jahangiri2013ACL,
  title={A comprehensive long-term retrospective analysis of silent corticotrophic adenomas vs hormone-negative adenomas.},
  author={Arman Jahangiri and Jeffrey R. Wagner and Melike Pekmezci and Anne Hiniker and Edward F. Chang and Sandeep M Kunwar and Lewis S. Blevins and Manish K Aghi},
  journal={Neurosurgery},
  year={2013},
  volume={73 1},
  pages={8-17; discussion 17-8}
}
BACKGROUND Silent corticotrophic adenomas (SCAs) stain adrenocorticotropic hormone (ACTH)+ without causing Cushing disease. SCAs are reportedly more aggressive, but information comes from small series. OBJECTIVE To determine whether SCAs behave more aggressively than hormone-negative adenomas (HNAs), and characterize SCA ACTH production alterations. METHODS SCAs (n = 75) and HNAs (n = 1726) diagnosed at our institution from 1990 to 2011 were retrospectively reviewed. RT-PCR was used to… CONTINUE READING