A comprehensive evidence-based approach to fever of unknown origin.

  title={A comprehensive evidence-based approach to fever of unknown origin.},
  author={Ophyr Mourad and Valerie A. Palda and Allan S. Detsky},
  journal={Archives of internal medicine},
  volume={163 5},
BACKGROUND Fever of unknown origin (FUO) is defined as a temperature higher than 38.3 degrees C on several occasions and lasting longer than 3 weeks, with a diagnosis that remains uncertain after 1 week of investigation. METHODS A systematic review was performed to develop evidence-based recommendations for the diagnostic workup of FUO. MEDLINE database was searched (January 1966 to December 2000) to identify articles related to FUO. Articles were included if the patient population met the… CONTINUE READING


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