A comprehensive approach to the molecular determinants of lifespan using a Boolean model of geroconversion.


Altered molecular responses to insulin and growth factors (GF) are responsible for late-life shortening diseases such as type-2 diabetes mellitus (T2DM) and cancers. We have built a network of the signaling pathways that control S-phase entry and a specific type of senescence called geroconversion. We have translated this network into a Boolean model to… (More)
DOI: 10.1111/acel.12504