A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells.

@article{Kang2009ACA,
  title={A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells.},
  author={Quan Kang and Wen-Xin Song and Qingyang Luo and Ni Tang and Jinyong Luo and Xiaoji Luo and Jin Chen and Yang Bi and Bai-Cheng He and Jong Kyung Park and Wei Jiang and Yi Tang and Jiayi Huang and Yuxi Su and Gao-Hui Zhu and Yun He and Hong Yin and Zhenming Hu and Yi Wang and Liang Chen and Guo-wei Zuo and Xiaochuan Pan and Jikun Shen and Tamara Vokes and Russell R. Reid and Rex C. Haydon and Hue H. Luu and T. X. He},
  journal={Stem cells and development},
  year={2009},
  volume={18 4},
  pages={545-59}
}
Pluripotent mesenchymal stem cells (MSCs) are bone marrow stromal progenitor cells that can differentiate into osteogenic, chondrogenic, adipogenic, and myogenic lineages. Several signaling pathways have been shown to regulate the lineage commitment and terminal differentiation of MSCs. Here, we conducted a comprehensive analysis of the 14 types of bone morphogenetic protein (BMPs) for their abilities to regulate multilineage specific differentiation of MSCs. We found that most BMPs exhibited… CONTINUE READING
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