A comprehensive analysis of the CDKN2A gene in childhood acute lymphoblastic leukemia reveals genomic deletion, copy number neutral loss of heterozygosity, and association with specific cytogenetic subgroups.

@article{Sulong2009ACA,
  title={A comprehensive analysis of the CDKN2A gene in childhood acute lymphoblastic leukemia reveals genomic deletion, copy number neutral loss of heterozygosity, and association with specific cytogenetic subgroups.},
  author={Sarina Sulong and Anthony V Moorman and Julie A E Irving and Jonathan C. Strefford and Zoe J Konn and Marian C Case and Lynne Minto and Kerry E Barber and Helen L Parker and Sarah L. Wright and Adam R M Stewart and Simon Bailey and Nick P Bown and Andrew G Hall and Christine J Harrison},
  journal={Blood},
  year={2009},
  volume={113 1},
  pages={100-7}
}
Inactivation of the tumor suppressor gene, CDKN2A, can occur by deletion, methylation, or mutation. We assessed the principal mode of inactivation in childhood acute lymphoblastic leukemia (ALL) and frequency in biologically relevant subgroups. Mutation or methylation was rare, whereas genomic deletion occurred in 21% of B-cell precursor ALL and 50% of T-ALL patients. Single nucleotide polymorphism arrays revealed copy number neutral (CNN) loss of heterozygosity (LOH) in 8% of patients. Array… CONTINUE READING
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