A comprehensive DNA methylation profile of epithelial-to-mesenchymal transition.

  title={A comprehensive DNA methylation profile of epithelial-to-mesenchymal transition.},
  author={Francisco J Carmona and Ver{\'o}nica D{\'a}valos and Enrique Vidal and Antonio G{\'o}mez and Holger Heyn and Yutaka Hashimoto and M. Teresa Vizoso and Anna Mart{\'i}nez-Card{\'u}s and Sergi Sayols and Humberto J. Ferreira and Jose Vicente Sanchez-Mut and Sebastian Moran and M Carmen Margel{\'i} and Eva Castell{\`a} and Mar{\'i}a Berdasco and Olafur Stefansson and Jorunn Erla Eyfjord and Eva Gonz{\'a}lez-Su{\'a}rez and Joaqu{\'i}n Dopazo and Modesto Orozco and Ivo G Gut and Manel Esteller},
  journal={Cancer research},
  volume={74 19},
Epithelial-to-mesenchymal transition (EMT) is a plastic process in which fully differentiated epithelial cells are converted into poorly differentiated, migratory and invasive mesenchymal cells, and it has been related to the metastasis potential of tumors. This is a reversible process and cells can also eventually undergo mesenchymal-to-epithelial transition. The existence of a dynamic EMT process suggests the involvement of epigenetic shifts in the phenotype. Herein, we obtained the DNA… CONTINUE READING
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