A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease

  title={A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease},
  author={Majid Do Nikpay and Anuj Goel and Hong-Hee Won and Leanne M Hall and Christina Willenborg and Stavroula Kanoni and Danish Saleheen and Theodosios Kyriakou and Christopher P. Nelson and Jemma C. Hopewell and Thomas R. Webb and Lingyao Zeng and Abbas Dehghan and Maris Alver and Sebastian M. Armasu and Kirsi Auro and Andrew C. Bjonnes and Daniel Chasman and Shufeng Chen and Ian Ford Ford and Nora Franceschini and Christian Gieger and Christopher Grace and Stefan Gustafsson and Jie Tang Yan Huang and S. -Y. Hwang and Yun Kyoung Kim and Marcus E. Kleber and King Wai Lau and Xiangfeng Lu and Yingchang Lu and Leo-Pekka Lyytik{\"a}inen and Evelin Mihailov and Alanna C. Morrison and Natalia Pervjakova and Liming Qu and Lynda M. Rose and Elias L Salfati and R Singh Saxena and Markus Scholz and Albert Vernon Smith and Emmi Tikkanen and Andr{\'e} G. Uitterlinden and X Frank Yang and Weihua Zhang and Wei Zhao and Mariza de Andrade and Paul S. de Vries and Natalie R van Zuydam and Sonia Savitri Anand and Lars Bertram and Frank Beutner and George V. Z. Dedoussis and Philippe M. Frossard and Dominique Gauguier and Alison H. Goodall and Omri Gottesman and Marc Haber and Bok-ghee Han and Jianfeng F Huang and Shapour Jalilzadeh and Thorsten Kessler and Inke R. K{\"o}nig and Lars Lannfelt and Wolfgang Lieb and Lars Lind and Cecilia M. Lindgren and Marja-Liisa L Lokki and Patrik K. E. Magnusson and Nadeem Hayyat Mallick and Narinder K Mehra and Thomas Meitinger and Fazal-ur-Rehman Memon and Andrew P. Morris and Markku S Nieminen and Nancy L Pedersen and Annette Peters and Loukianos S Rallidis and A Muzib Hassanal Rasheed and Maria Samuel and Svati H. Shah and Juha Sinisalo and Kathleen E. Stirrups and Stella Trompet and Laiyuan Wang and Khan Shah Zaman and Diego Ardissino and Eric Boerwinkle and Ingrid B. Borecki and Erwin P. Bottinger and Julie E. Buring and John Campbell Chambers and Rory Collins and L. Adrienne Cupples and John Danesh and Ilja Demuth and Roberto Elos{\'u}a and Stephen E. Epstein and T{\"o}nu Esko and Mary F Feitosa and O. H. Franco and Maria Grazia Franzosi and Christopher B. Granger and Dongfeng Gu and Vilmundur Gudnason and Alistair Scott Hall and Anders Hamsten and Tamara B. Harris and Stanley L. Hazen and Christian Hengstenberg and Albert Hofman and Erik Ingelsson and Carlos Iribarren and J Wouter Jukema and Pekka J. Karhunen and Bong-Jo Kim and Jaspal Singh Kooner and Iftikhar J. Kullo and Terho Lehtim{\"a}ki and Ruth J. F. Loos and Olle Melander and Andres Metspalu and Winfried Maerz and Colin N A Palmer and Markus Perola and Thomas Quertermous and Daniel J. Rader and Paul M. Ridker and Samuli Ripatti and Robert Roberts and Veikko V Salomaa and Dharambir Kaur Sanghera and Stephen M Schwartz and Udo Seedorf and Alexandre F. R. Stewart and David Stott and Joachim Thiery and Pierre A. Zalloua and Christopher J. O’Donnell and Muredach P. Reilly and Themistocles L. Assimes and John R. Thompson and Jeanette Erdmann and Robert J. Clarke and Hugh C. Watkins and Sekar Kathiresan and Ruth Mcpherson and Panagiotis Deloukas and Heribert Schunkert and Nilesh J. Samani and Martin Farrall},
  booktitle={Nature Genetics},
Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association study (GWAS) analysis of common SNPs. Leveraging phased haplotypes from the 1000 Genomes Project, we report a GWAS meta-analysis of ∼185,000 CAD cases and controls, interrogating 6.7 million common (minor allele frequency (MAF) > 0.05) and 2.7 million low-frequency (0.005 < MAF < 0.05) variants. In addition to confirming most known CAD-associated loci, we identified… CONTINUE READING
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