A composite upstream sequence motif potentiates tRNA gene transcription in yeast.

@article{Giuliodori2003ACU,
  title={A composite upstream sequence motif potentiates tRNA gene transcription in yeast.},
  author={Silvia Giuliodori and Riccardo Percudani and Priscilla Braglia and Roberto Ferrari and Elisa Guffanti and Simone Ottonello and Giorgio Dieci},
  journal={Journal of molecular biology},
  year={2003},
  volume={333 1},
  pages={1-20}
}
Transcription of eukaryotic tRNA genes relies on the TFIIIC-dependent recruitment of TFIIIB on a approximately 50 bp region upstream of the transcription start site (TSS). TFIIIC specifically interacts with highly conserved, intragenic promoter elements, while the contacts between TFIIIB and the upstream DNA have long been considered as largely non-specific. Through a computer search procedure designed to detect shared, yet degenerate sequence features, we have identified a conserved sequence… CONTINUE READING

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