A composite intronic element directs dynamic binding of the progesterone receptor and GATA-2.

@article{Magklara2009ACI,
  title={A composite intronic element directs dynamic binding of the progesterone receptor and GATA-2.},
  author={Angeliki Magklara and Catharine L. Smith},
  journal={Molecular endocrinology},
  year={2009},
  volume={23 1},
  pages={61-73}
}
The progesterone receptor (PR) plays a pivotal role in proper development and function of the mammary gland and has also been implicated in mammary tumorigenesis. PR is a ligand-activated transcription factor; however, relatively, little is known about its mechanisms of action at endogenous target promoters. The aim of our study was to identify a natural PR-responsive gene and investigate its transcriptional regulation in the mammary microenvironment. Our experiments revealed FKBP5 as a direct… CONTINUE READING

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