A composite dermal filler comprising cross-linked hyaluronic acid and human collagen for tissue reconstruction.

  title={A composite dermal filler comprising cross-linked hyaluronic acid and human collagen for tissue reconstruction.},
  author={Z-Hun Kim and Yongjun Lee and Sun-mi Kim and Hojin Kim and Chang-Koo Yun and Yong‐Soo Choi},
  journal={Journal of microbiology and biotechnology},
  volume={25 3},
In this study, we developed a composite filler comprising cross-linked hyaluronic acid (HA) and human collagen (COL) derived from the human umbilical cord with the aim of improving its biocompatibility and longevity compared with commercially available fillers. After HA/ COL composite fillers were made in two different ratios (10:1 and 5:1), the physical properties of the fillers were evaluated. The interior morphologies and in vivo weight change of these hydrogels were also characterized at 1… 

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