Corpus ID: 25817662

A complex syndrome of left-right axis, central nervous system and axial skeleton defects in Zic3 mutant mice.

@article{Purandare2002ACS,
  title={A complex syndrome of left-right axis, central nervous system and axial skeleton defects in Zic3 mutant mice.},
  author={S. Purandare and S. Ware and K. Kwan and M. Gebbia and M. Bassi and J. Deng and H. Vogel and R. Behringer and J. Belmont and B. Casey},
  journal={Development},
  year={2002},
  volume={129 9},
  pages={
          2293-302
        }
}
X-linked heterotaxy (HTX1) is a rare developmental disorder characterized by disturbances in embryonic laterality and other midline developmental field defects. HTX1 results from mutations in ZIC3, a member of the GLI transcription factor superfamily. A targeted deletion of the murine Zic3 locus has been created to investigate its function and interactions with other molecular components of the left-right axis pathway. Embryonic lethality is seen in approximately 50% of null mice with an… Expand
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