A complex secretory program orchestrated by the inflammasome controls paracrine senescence

  title={A complex secretory program orchestrated by the inflammasome controls paracrine senescence},
  author={Juan Carlos Acosta and Ana Banito and Torsten Wuestefeld and Athena Georgilis and Peggy Janich and Jennifer P Morton and Dimitris Athineos and Tae-Won Kang and Felix Lasitschka and Mindaugas Andrulis and Gloria Pascual and Kelly J. Morris and Sadaf Khan and Hong Jin and Gopuraja Dharmalingam and Ambrosius P Snijders and Thomas S. Carroll and David R. Capper and Catrin A. Pritchard and Gareth J Inman and Thomas Longerich and Owen J Sansom and Salvador Aznar Benitah and Lars Zender and Jes{\'u}s Gil},
  booktitle={Nature Cell Biology},
Oncogene-induced senescence (OIS) is crucial for tumour suppression. Senescent cells implement a complex pro-inflammatory response termed the senescence-associated secretory phenotype (SASP). The SASP reinforces senescence, activates immune surveillance and paradoxically also has pro-tumorigenic properties. Here, we present evidence that the SASP can also induce paracrine senescence in normal cells both in culture and in human and mouse models of OIS in vivo. Coupling quantitative proteomics… CONTINUE READING
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