A complex phosphodiesterase system controls beta-adrenoceptor signalling in cardiomyocytes.

@article{Mongillo2006ACP,
  title={A complex phosphodiesterase system controls beta-adrenoceptor signalling in cardiomyocytes.},
  author={Marco Mongillo and Manuela Zaccolo},
  journal={Biochemical Society transactions},
  year={2006},
  volume={34 Pt 4},
  pages={510-1}
}
beta-Adrenergic signalling mediates the positive inotropic effect of catecholamines on cardiomyocytes, mainly through cAMP generation and subsequent activation of PKA (protein kinase A). Given the large diversity of PKA targets within cardiac cells, a precisely regulated and confined activity of such signalling pathways is essential for the specificity of response. PDEs (phosphodiesterases) constitute the only cAMP-degrading mechanism and are expressed in the cardiomyocyte in at least 5 family… CONTINUE READING
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