A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis.

@article{Aparicio2000ACM,
  title={A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis.},
  author={Jes{\'u}s F Aparicio and Roberto Fouces and Marta Vaz Mendes and Nicol{\'a}s Socarr{\'a}s Olivera and Juan F. Martin},
  journal={Chemistry & biology},
  year={2000},
  volume={7 11},
  pages={
          895-905
        }
}
BACKGROUND Polyene macrolides are a class of large macrocyclic polyketides that interact with membrane sterols, having antibiotic activity against fungi but not bacteria. Their rings include a chromophore of 3-7 conjugated double bonds which constitute the distinct polyene structure. Pimaricin is an archetype polyene, important in the food industry as a preservative to prevent mould contamination of foods, produced by Streptomyces natalensis. We set out to clone, sequence and analyse the gene… CONTINUE READING
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