A complex intronic enhancer regulates expression of the CFTR gene by direct interaction with the promoter

@inproceedings{Ott2009ACI,
  title={A complex intronic enhancer regulates expression of the CFTR gene by direct interaction with the promoter},
  author={Christopher J. Ott and Magdalena I Suszko and Neil P. Blackledge and Jane E. Wright and Gregory E. Crawford and Ann Marie Harris},
  booktitle={Journal of cellular and molecular medicine},
  year={2009}
}
Genes can maintain spatiotemporal expression patterns by long-range interactions between cis-acting elements. The cystic fibrosis transmembrane conductance regulator gene (CFTR) is expressed primarily in epithelial cells. An element located within a DNase I-hypersensitive site (DHS) 10 kb into the first intron was previously shown to augment CFTR promoter activity in a tissue-specific manner. Here, we reveal the mechanism by which this element influences CFTR transcription. We employed a high… CONTINUE READING
27 Citations
51 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 51 references

Longrange chromosomal interactions regulate the timing of the transition between poised and active gene expression

  • D Vernimmen, MD Gobbi, JA SloaneStanley, WG Wood, DR. Higgs
  • EMBO J
  • 2007
1 Excerpt

Similar Papers

Loading similar papers…