A complex composed of tup1 and ssn6 represses transcription in vitro.

@article{Redd1997ACC,
  title={A complex composed of tup1 and ssn6 represses transcription in vitro.},
  author={Michael J. Redd and Martha B. Arnaud and Alexander Johnson},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 17},
  pages={11193-7}
}
The Saccharomyces cerevisiae Tup1 protein is a member of a family of WD repeat containing proteins that are involved in repression of transcription. Tup1, along with the Ssn6 protein, represses a wide variety of genes in yeast including cell type-specific and glucose-repressed genes. Tup1 and Ssn6 are recruited to these specific gene sets by interaction with sequence-specific DNA binding proteins. In this work, a protein complex containing Ssn6 and Tup1 was purified to determine its composition… CONTINUE READING

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