A complex barcode underlies the heterogeneous response of p53 to stress

@article{MurrayZmijewski2008ACB,
  title={A complex barcode underlies the heterogeneous response of p53 to stress},
  author={Fiona Murray-Zmijewski and Elizabeth Audrey. Slee and Xin Xu},
  journal={Nature Reviews Molecular Cell Biology},
  year={2008},
  volume={9},
  pages={702-712}
}
The tumour suppressor p53 is activated following stress and initiates a heterogeneous response in a cell-, tissue- and stress-dependent manner. This heterogeneity is reflected in the different physiological outcomes that follow p53 activation. One mechanism that may contribute to this variability is the promoter selectivity of p53 target genes. p53 is at the hub of numerous signalling pathways that are triggered in response to particular stresses, all of which can leave their mark on p53 by way… CONTINUE READING
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