A complex DNA-repeat structure within the Selenoprotein P promoter contains a functionally relevant polymorphism and is genetically unstable under conditions of mismatch repair deficiency

@article{AlTaie2002ACD,
  title={A complex DNA-repeat structure within the Selenoprotein P promoter contains a functionally relevant polymorphism and is genetically unstable under conditions of mismatch repair deficiency},
  author={Oliver Hatem Al-Taie and Jochen Seufert and Hubert M{\"o}rk and Holger Treis and Birgit Mentrup and Andreas Thalheimer and Petr Starostik and Josef Abel and Michael Scheurlen and Josef Koehrle and Franz Jakob},
  journal={European Journal of Human Genetics},
  year={2002},
  volume={10},
  pages={499-504}
}
Epidemiological data, animal studies and interventional studies provide evidence for a potential chemopreventive effect of selenium during development of colorectal cancer. The human glycoprotein Selenoprotein P (SeP) contains up to 50% of plasma selenium content. SeP is expressed in the gastrointestinal tract and the liver, where its expression is downregulated by various proinflammatory cytokines (Il1β, TGFβ, IFNγ). Previously, we have demonstrated dramatically reduced SeP expression in human… CONTINUE READING
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