A complex 'mRNA degradation code' controls gene expression during animal development.

@article{Alonso2012AC,
  title={A complex 'mRNA degradation code' controls gene expression during animal development.},
  author={Claudio R Alonso},
  journal={Trends in genetics : TIG},
  year={2012},
  volume={28 2},
  pages={78-88}
}
Current understanding of the molecular mechanisms underlying mRNA degradation indicates that specific mRNA degradation rates are primarily encoded within the mRNA message itself in the form of cis-regulatory elements bearing particular primary sequences and/or secondary-structures. Such control elements are operated by RNA-binding proteins (RBPs) and/or miRNA-containing complexes. Based on the large number of RBPs and miRNAs encoded in metazoan genomes, their complex developmental expression… CONTINUE READING

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