A complete genomic analysis of hepatitis B virus genotypes and mutations in HBeAg-negative chronic hepatitis B in China.

@article{Zhu2008ACG,
  title={A complete genomic analysis of hepatitis B virus genotypes and mutations in HBeAg-negative chronic hepatitis B in China.},
  author={Lijun Zhu and C-H Tse and Vincent Wai-Sun Wong and Angel M-L Chim and K-S. Leung and Henry L. Y. Chan},
  journal={Journal of viral hepatitis},
  year={2008},
  volume={15 6},
  pages={449-58}
}
We aimed to study the distribution of hepatitis B virus (HBV) genotypes/subgenotypes in different parts of China and their clinical impact on the severity of hepatitis B e antigen (HBeAg)-negative chronic hepatitis B. Residual serum samples from a cohort of HBeAg-negative chronic hepatitis B patients in Hong Kong, Shanghai and Beijing were studied. Complete HBV genomic sequencing was performed for phylogenetic tree analysis and determination of HBV mutations was carried out. Mutations… CONTINUE READING