A complete duplication of X chromosome resulting in a tricentric isochromosome originated by centromere repositioning


Neocentromeres are rare and considered chromosomal aberrations, because a non-centromeric region evolves in an active centromere by mutation. The literature reported several structural anomalies of X chromosome and they influence the female reproductive capacity or are associated to Turner syndrome in the presence of monosomy X cell line. We report a case… (More)
DOI: 10.1186/s13039-017-0323-7


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