A complement receptor-1 polymorphism with high frequency in malaria endemic regions of Asia but not Africa

@article{Thomas2005ACR,
  title={A complement receptor-1 polymorphism with high frequency in malaria endemic regions of Asia but not Africa},
  author={Bolaji n. Thomas and B{\'e}atrice Donvito and Ian A. Cockburn and Thierry Fandeur and J Alexandra Rowe and Jacques Henri Max Cohen and Joann M. Moulds},
  journal={Genes and Immunity},
  year={2005},
  volume={6},
  pages={31-36}
}
Complement receptor-1 (CR1) is a ligand for rosette formation, a phenomenon associated with cerebral malaria (CM). Binding is dependent on erythrocyte CR1 copy number. In Caucasians, low CR1 expressors have two linked mutations. We determined the Q981H and HindIII RFLP distribution in differing population groups to ascertain a possible role in adaptive evolution. We examined 194 Caucasians, 180 Choctaw Indians, 93 Chinese-Taiwanese, 304 Cambodians, 89 Papua New Guineans (PNG) and 366 Africans… CONTINUE READING
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